Data Fraud in Clinical Trials

“Highly publicized cases of fabrication or falsification of data in clinical trials have occurred in recent years and it is likely that there are additional undetected or unreported cases. We review the available evidence on the incidence of data fraud in clinical trials, describe several prominent cases, present information on motivation and contributing factors and discuss cost-effective ways of early detection of data fraud as part of routine central statistical monitoring of data quality. Adoption of these clinical trial monitoring procedures can identify potential data fraud not detected by conventional on-site monitoring and can improve overall data quality.”


Source

NCBI: Data fraud in clinical trials

Barbershop-Based Healthcare Study Lowers High Blood Pressure in African-American Men

“New England Journal of Medicine: Nearly 64% Reduced Their Blood Pressure to Healthy Levels After Barbers Promoted Follow-Up With Pharmacists in the Barbershops.

“African-American men lowered their high blood pressure to healthy levels when aided by a pharmacist and their barber, according to a new study from the Smidt Heart Institute.”


Source

Cedars Sinai: Barbershop-Based Healthcare Study Lowers High Blood Pressure in African-American Men

100 years of the FDA

“The 1906 pure food and drug act was set up to protect US citizens from unregulated and potentially harmful products. Implementing the regulation has presented the US Food and Drug Administration with many high-profile challenges, as Fiona Case finds out.”

Read more


Source

Chemistry World: 100 years of the FDA (2006) by Fiona Case

Invalidating Bloodletting with Science

Blood on the Tracks – Podcast Episode 38

Learn about a piece of epidemiological history: one of the earliest examples of population-level clinical studies influencing medical practice. This podcast tells the story of how French physician Pierre Charles Alexandre Louis studied a group of patients and ended up discovering quantitative evidence on the detriment of bloodletting. Learning the history helps place these tools in a broader context, which isn’t crucial, but interesting nonetheless.

Listen to the Podcast here

The first population study in history was born out of a dramatic debate involving leeches, “medical vampires,” professional rivalries, murder accusations, and, of course, bloodletting, all in the backdrop of the French Revolution. The second of a multipart series on the development of population medicine, this episode contextualizes Pierre Louis’ “numerical method,” his famous trial on bloodletting, and the birth of a new way for doctors to “know”.


Source

Bedside Rounds: Episode 38: Blood on the Tracks (PopMed #2)

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